Effect of Short-term Oxygen During CPET in HFpEF

University of Zurich10 enrolled

Overview

In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with heart failure with preserved ejection fraction.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Heart Failure, Diastolic (HFpEF)

Interventions

Oxygen applicationPROCEDURE

Oxygen application Supplemental oxygen via mask

Sham room airPROCEDURE

Room air will be applied via mask

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HFpEF, stable medication for at least 4 weeks. Exclusion Criteria: * instable status, pregnancy, clinically relevant concomitant diseases, inability to follow the study procedures

Locations (1)

University Hospital Zurich, Division of Pneumology

Zurich, Switzerland

Outcomes

Primary Outcomes

Work Rate (Watt)

Maximal Work Rate (Watt max) measured during cardiopulmonary exercise test oxygen vs. room air

Time frame: 1 day

Endurance Time (s)

Endurance (s) with 75% Wmax measured during cardiopulmonary exercise test oxygen vs. room air

Time frame: 1 day