CAR T cells targeting CD19 have been approved for patients with relapsed or refractory ALL, failing two or more prior protocols. Several institutional-based studies with other CAR T cells targeting CD19 have demonstrated outstanding response rates in patients with refractory disease, and the ability of CAR T cells to clear CNS leukemia. Nevertheless, these cases are sparse and have never been reported collectively. Here, we aim to retrospectively assess toxicity and long term outcome of patients treated with CAR T cells for CNS relapse of ALL.
Study Type
OBSERVATIONAL
Enrollment
80
Chaim Sheba Medical Center
Ramat Gan, Israel
Overall survival
Duration between CAR T-cell infusion and death or last follow-up, according to Kaplan-Meier analysis
Time frame: 6 months
Incidence of CAR-related CRS or ICANS per ASCTC guidelines
Number of patients and average grade of cytokine-release syndrome and immune-effector cell associated neurotoxicity syndrome within 2 months after CAR treatment, according to ASCTC guidelines (Lee et al, BBMT 2019)
Time frame: 2 months
Leukemia-free survival
Duration between CAR T-cell infusion and leukemia relapse, according to Kaplan-Meier analysis
Time frame: 6 months
CNS-leukemia free survival
Duration between CAR T-cell infusion and CNS leukemia relapse, according to Kaplan-Meier analysis
Time frame: 6 months
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