The main purpose of this study is to see if the drug LY3200882 which is an inhibitor of transforming growth factor-β (TGFβ) receptor 1 in combination with pembrolizumab is safe and effective in participants with cancer that has spread to other parts of the body.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
LY3200882 administered orally
Pembrolizumab administered IV
Dana Farber Cancer Institute
Boston, Massachusetts, United States
CHU de Besancon Hopital Jean Minjoz
Besançon, France
Gustave Roussy
Villejuif, France
Institut Catala d'Oncologia
L'Hospitalet de Llobregat, Barcelona, Spain
Number of Participants with Dose Limiting Toxicity (DLT)
Number of Participants with DLT
Time frame: Up to 6 Weeks
Overall Response Rate (ORR): Percentage of Participants with Complete Response (CR) or Partial Response (PR)
ORR: Percentage of Participants with CR or PR
Time frame: Baseline through Disease Progression or Death (Estimated at up to 12 Months)
Pharmacokinetics (PK): Maximum Observed Drug Concentration (Cmax) of LY3200882 in Combination With Pembrolizumab
PK: Cmax of LY3200882 in Combination With Pembrolizumab
Time frame: Baseline through Week 13
Duration of Response (DoR)
DoR
Time frame: Date of CR or PR to Date of Disease Progression or Death Due to Any Cause (Estimated at up to 12 Months)
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Hospital Clinic I Provincial
Barcelona, Spain
Hospital Madrid Norte Sanchinarro
Madrid, Spain