Prevalence and Spectrum of Cancer Susceptibility Among Patients with Advanced Colorectal Polyps

University of Colorado, Denver200 enrolled

Overview

The study is being conducted to determine the prevalence and risk factors for germline cancer susceptibility genetic mutations among patients with advanced colorectal polyps.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Colorectal Neoplasm

Interventions

Multi-Cancer Cancer PanelGENETIC

Eligible patients will receive genetic testing to determine germline cancer predisposition.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 89 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Provision to sign and date the consent form * Stated willingness to comply with all study procedures and be available for the duration of the study * Be a male or female aged 18-89 * Undergone colonoscopy * At least one advanced colorectal polyp, defined as having any of the following: * Any polyp ≥ 1cm (adenoma or serrated polyp) * Any polyp with villous architecture * Any polyp with high-grade dysplasia * Sessile serrated polyps with any dysplasia * Traditional serrated adenoma Exclusion Criteria: * Known hereditary cancer syndrome * Personal history of inflammatory bowel disease * Personal history of colorectal cancer * Polyp histology or size unavailable or not documented

Locations (1)

University of Colorado Denver

Aurora, Colorado, United States

Outcomes

Primary Outcomes

Prevalence of germline pathogenic/likely pathogenic variants in cancer predisposition genes in patients with advanced colorectal polyps

Time frame: 3 years

Secondary Outcomes

Risk factors for germline pathogenic/likely pathogenic variants in patients with advanced colorectal polyps

Time frame: 3 years

Data from ClinicalTrials.gov

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