Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children

Bezmialem Vakif University76 enrolled

Overview

The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.

The impaired airway clearence and pulmonary functions, exercise intolerance, low physical activity level and decreased peripheral muscle strength make physiotherapy approaches important in the management of CF and PCD.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Primary Ciliary Dyskinesia Cystic Fibrosis

Interventions

Measurement of functional capacityOTHER

Functional capacity of participants will be measured with six-minute walk test.

pulmonary function testOTHER

It will be measured using basic spirometry and presented lung volume parameters such as FEV1,FVC,FEV1/FVC,PEF, FEF25-75

Functional capacityOTHER

Functional capacity of participants will be measured with six-minute walk test and sit-to-stand test

Eligibility

Sex: ALLMin age: 6 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of cystic fibrosis or primary ciliary dyskinesia Exclusion Criteria: * Hospitalization history in past month * Diagnosis of other chronic pediatric diseases which may impair exercise tolerance such as cerebral palsy or neuromuscular disease * Candidates for lung transplantation or history of lung transplantation

Locations (1)

Bezmialem Vakıf University

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Six-minute walk test distance

Distance walked in six minutes will be recorded in meters. Test will be conducted according to the guideline of American Thoracic Society (ATS).

Time frame: 15 minutes

Secondary Outcomes

Forced Vital Capacity (FVC)

FVC will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)

Time frame: 5 minutes

Forced Expiratory Volume in 1 second (FEV1)

FEV1 will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)

Time frame: 5 minutes

Peak Expiratory Flow (PEF)

PEF will be measured using basic spirometry and expressed as the percentage of the predicted value according to the guideline of European Respiratory Society (ERS)

Time frame: 5 minutes

M. Quadriceps strength

Isometric M. Quadriceps strength (kg) will be measured using electronic hand held dynamometer in sitting position.

Time frame: 5 minutes

Data from ClinicalTrials.gov

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