Single Cell Sequencing Analysis of Thymoma

Zhejiang Cancer Hospital10 enrolled

Overview

The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Thymoma

Interventions

TissueDIAGNOSTIC_TEST

Four 4-5 mm tissues of the thymoma

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with thymoma * Ability to provide written consent and comply with the protocol * At least 18 years of age Exclusion Criteria: * Patients undergoing thymoma treatment * Patients with previous malignancy * Known HIV positive status. * Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.

Locations (1)

An Zhao

Hangzhou, China

RECRUITING

Outcomes

Primary Outcomes

Determination of cell population from thymoma

The genes expression and the cell population

Time frame: through study completion, an average of 1 year

Central Contacts

An ZHAO, MD, PHD

CONTACT

8688122413 zhaoan@zjcc.org.cn

Data from ClinicalTrials.gov

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