Effect of Papaverine on Renal Artery Blood Flow Volume

Asan Medical Center96 enrolled

Overview

The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery.

The purpose of this study is to evaluate the effect of papaverine on renal artery blood flow after declamping of renal artery in patients undergoing robot assisted partial nephrectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

Conditions

Kidney Cancer

Interventions

PapaverineDRUG

Immediately after the renal artery declamping, papaverine 30 mg (1 ample, 1 ml) is mixed with 5 ml of normal saline (total 6 ml) and sprinkled around the renal artery.

Normal salineDRUG

Immediately after the renal artery declamping, normal saline 6 ml is sprinkled around the renal artery.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 79 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with kidney cancer. * Patients undergoing robot assisted partial nephrectomy under general anesthesia * 20 years old ≤ age \<80 years old * Patients who voluntarily agreed to this clinical study * eGFR ≥ 60 ml / min / 1.73 m2 (Chronic Kidney Disease Epidemiology Patients with Collaboration) Exclusion Criteria: * The tumor ≥ 7 cm in size * Multiple renal mass * If the surgery plan is changed due to open * When surgery is performed together with other surgery * Multiple renal artery * Patients with hypersensitivity to papaverine * Patients with atrioventricular block * Pregnant and lactating women * Patients using levodopa * Refusal of patient

Locations (1)

Asan medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

Renal artery blood flow

Renal artery blood flow 2 minutes after papaverine administration by doppler sonography

Time frame: at 2 minutes after papaverine administration