Multimodal Connectome Study of Brain Tumor-operated Patients

N/AActive Not RecruitingNCT04163315

Centre Hospitalier Universitaire de Nice30 enrolled

Overview

In this pilot study, the investigators propose a multimodal evaluation of the brain connectivity of brain tumor patients, in order to better understand the effects induced by focal lesions on brain structure and function, as well as brain plasticity mechanisms that may occur in such condition. The investigators aim at drawing a multimodal brain connectivity map of focally brain-damaged patients, with a view to improve onco-functional neurosurgical practices.

Patients included in the present study will first perform the pre-operative MRI (dMRI and fMRI) with a specific High Resolution Angular Diffusion (HARDI) sequence and a functional acquisition at rest. Then, the investigators will record their cortico-cortical evoked potentials elicited by direct electrostimulation during the surgery, just before the tumor removal, following our usual protocol. Finally, all data (clinical, diffusion, electrical and functional connectivity) will be processed and correlated to each other.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Tumor, Brain

Interventions

dMRI, fMRI and electrocorticographyOTHER

Patients included in the study will perform the pre-operative MRI (fMRI and fMRI) with a specific High Resolution Angular Diffusion (HARDI) sequence and a functional rest sequence. The additional scan time for this specific sequence is approximately 25 minutes, with no foreseeable negative impact on the patient

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All patients with brain tumor for removal * Age \> 18 years * Informed patient consent * Membership of social security scheme Exclusion Criteria: * Contraindication to MRI * Any subject with vascular stent implanted less than 6 weeks prior to the exam; * Any subject carrying an intraocular or intracranial ferromagnetic foreign object close to nerve structures; * Any subject carrying biomedical equipment such as a cardiac, neuronal or sensory pacemaker (cochlear implant) or a ventricular bypass valve without medical and paramedical supervision trained in the performance of MRI in these subjects; * Presence of more than one brain tumor * Refusal of patient participation * Pregnant or nursing women. A urinary pregnancy test will be conducted for women of childbearing age. The results will be communicated to the patient by a doctor of her choice. * Person staying in a health or social establishment * Person in emergency situation * Vulnerable patient: deprived of liberty, guardianship, curators, or safeguarding of justice

Locations (1)

CHU de Nice

Nice, CHU de NICE, France

Outcomes

Primary Outcomes

Correlations between tumor topography, cortical electrical conduction rates measured in electrocorticography, and microstructural measurements of white substance from diffusion MRI

Time frame: 1 month

Secondary Outcomes

Correlations between neurological disorders, tumor topography and network disruption identified in functional rest MRI

Time frame: 1 month

Data from ClinicalTrials.gov

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