The Effects of Crocin Supplementation on Metabolic Parameters, Oxidative Stress, AMP- Activated Protein Kinase and Inflammation-promoting Genes Expression in Peripheral Blood Mononuclear Cells in Patients With Type 2 Diabetes

National Nutrition and Food Technology Institute50 enrolled

Overview

To study the effects of crocin supplement in patients with type 2 diabetes, 50 patients will be randomly allocated to placebo group and 2 tablets of crocin for 12 weeks. At the first and the end of the intervention, lipid profiles, blood pressure, blood sugar, inflammatory and anthropometric factors will be assessed and compared between groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Type 2 Diabetes

Interventions

crocinDIETARY_SUPPLEMENT

2 tablets crocin per day

placeboDIETARY_SUPPLEMENT

2 tablets placebo per day

Eligibility

Sex: ALLMin age: 40 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: Age of 40 to 65 years type 2 diabetes: and body mass index range of 18.5 to 30 kg/m2 Exclusion Criteria: pregnancy or lactation A history of Cardiovascular disease, Pulmonary disease, Renal disease

Locations (1)

National Nutrition and Food Technology Research Institute

Tehran, Iran

Outcomes

Primary Outcomes

type 2 diabetes

number of participants with normal plasma glucose

Time frame: 12 weeks

Data from ClinicalTrials.gov

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