Simultaneously PET/MRI in Prolonged DOC Patients

Hangzhou Normal University24 enrolled

Overview

Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Disorder of Consciousness Minimally Conscious State FDG-PET Rs-fMRI

Interventions

Multimodal NeuroimagingDIAGNOSTIC_TEST

fludeoxyglucose (FDG-)PET/MR imaging

Eligibility

Sex: ALLMin age: 16 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * DOC patients （acute, subacute or chronic period）: Coma, UWS and MCS. Exclusion Criteria: * neuromuscular blocking agents or sedative drugs administered within the prior 24 hours； * unstable medical condition； * mental implant in the brain

Locations (1)

International Vegetative State and Consciousness Science Institute, Hangzhou Normal University

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

resting-state fMRI

Use resting-state fMRI to test the functional connectivity

Time frame: Within 7 days

fludeoxyglucose (FDG-)PET

UseFDG-PET to test the metabolism.

Time frame: Within 7 days

Data from ClinicalTrials.gov

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