Effectiveness of Treatment With Rich Platelet Fibrin (PRF) VS Gold Standard in Patients Undergoing Knee Replacement

Inclusion Criteria: * Males or females undergoing a total knee prosthesis. * Willingness and ability to comply with the study procedures and visit schedules and ability to follow verbal and written instructions. * Hb \> 11 g/dl; Platelet value \> 150.000 plt/mmc; * Patients with non clinical alteration of ECG; * Signature of informed consent; Exclusion Criteria: * Patients incapable of understanding and of wanting; * Systemic disorders such as diabetes, rheumatic diseases; * Patients with malignancy; * Thyroid metabolic disorders ; * Abuse of alcohol, drugs and pharmaceutical drugs * Body mass index \> 40;