Using double-blind, randomized controlled design to compare the immediate, short-term and intermediate-term additional therapeutic effects of ultrasound-guided corticosteroid injection and dextrose injection of hyaluronic acid injection on patients with knee osteoarthritis, under the basis of International Classification of Functioning, Disability, and Health.
A total of 60 patients will be collected. The participants will be randomized into two groups, including hyaluronic acid combined corticosteroid group and hyaluronic acid combined dextrose group. The balance, physical activity (10 meters normal and fast walk, up and downstairs, and 5 repeated chair-rising time, timed up and go test), functional performance and knee-related quality of life (Western Ontario and McMaster Universities Osteoarthritis index、Knee Injury and Osteoarthritis Outcome Score) will be evaluated. All the evaluations will be re-evaluated at one week after injection, one month after injection, three months after injection, and six months after injection. Subjects and evaluators will be both blinded to the group's classification during the whole course of study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
60
compare the immediate effect (one week after 3 times of injections), short-term effects (one month and three months after 3 times of injections), and midterm effect (6 months after 3 times of injections).
Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taiwan
Western Ontario and McMaster Universities Osteoarthritis index
assess knee osteoarthritis related performance
Time frame: changes of scores from baseline to at one week, one month, 3 months and 6 months after 3 times of injections; score range: 0-100, higher scores mean a worse outcome
Balance
Berg Balance scale
Time frame: changes of scores from baseling to at one week, one month, 3 months and 6 months after 3 times of injections; score range 0-4, higher scores mean a better outcome
physical functional performance-walking
10 meters normal and fast walking speed
Time frame: change from baseline to at one week, one month, 3 months and 6 months after 3 times of injections
physical functional performance-stairs climbing
time for up and down stairs
Time frame: change from baseline to at one week, one month, 3 months and 6 months after 3 times of injections
physical functional performance-chair raising
5 repeated chair-rising time
Time frame: change from baseline to at one week, one month, 3 months and 6 months after 3 times of injections
physical functional performance-balance
timed up and go test
Time frame: change from baseline to at one week, one month, 3 months and 6 months after 3 times of injections
Knee Injury and Osteoarthritis Outcome Score
assess osteoarthritis of knee related function
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Time frame: changes of scores from baseline to at one week, one month, 3 months and 6 months after 3 times of injections; score range 0-100, higher scores mean at better outcome
Doppler resistance index
assess knee blood vessel resistance
Time frame: changes of scores from baseline to at one week after 1 time of injection and two weeks after 2 times of injection; the lower values indicate a low blood vessel resistance