Sleep and particularly deep sleep are playing an important role for brain and body health. Poor sleep has been associated with risk factors for cardiovascular disease and moreover, is hypothesized to increased mortality risk of cardiovascular diseases. Yet, the role of specific sleep processes for cardiovascular function remains unclear. Particularly deep sleep, which is manifested by large amplitude, low frequency oscillations is of importance for the restorative functions of sleep. Thus, the modulation of deep sleep by auditory stimulation will be of central interests to assess the cause-effect relationship of specific processes within sleep for cardiovascular regulation. This study will assess the effects of slow wave modulating auditory stimulation on cardiovasuclar functions in healthy male participants.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
71
Acoustic stimulation to modulate slow waves.
This is the sham-control intervention; only the biosignal will be recorded but no acoustic stimulation will be played.
ETH Zurich
Zurich, Schweiz, Switzerland
Cardiac autonomic regulation
assessed by heart rate variability derived from electrocardiography
Time frame: continuously across approximately 8 hours of sleep with and without acoustic stimulation
Change in cardiac autonomic regulation
assessed by changes in heart rate variability derived from electrocardiography
Time frame: Before to after approximately 8 hours of sleep with and without acoustic stimulation
Heart rate
measured with electrocardiography
Time frame: continuously across approximately 8 hours of sleep with and without acoustic stimulation
Change in heart rate
measured with electrocardiography
Time frame: Before to after approximately 8 hours of sleep with and without acoustic stimulation
Marker for sleep depth
Slow wave activity assessed with high-density electroencephalography(hdEEG)
Time frame: continuously across approximately 8 hours of sleep with and without acoustic stimulation
Change in vascular functioning
Assessed by outcomes of blood profiles of vascular inflammation, pulmonal arterial pressure, intima media thickness, or echocardiography
Time frame: Before and/or after approximately 8 hours of sleep with and without acoustic stimulation
Arterial pressure waveform
assessed by arterial pressure waveform measures
Time frame: continuously across approximately 8 hours of sleep with and without acoustic stimulation
Change in arterial pressure waveform
assessed by arterial pressure waveform measures
Time frame: Before to after approximately 8 hours of sleep with and without acoustic stimulation
Oxyen saturation
assessed by pulse oximetry
Time frame: continuously across approximately 8 hours of sleep with and without acoustic stimulation
Overnight memory consolidation
Assessed by memory tasks
Time frame: Before to after approximately 8 hours of sleep with and without acoustic stimulation
Changes in vigilance
assessed by simple vigilance task
Time frame: Before to after approximately 8 hours of sleep with and without acoustic stimulation
Changes in muscular fatigue
assessed by simple muscular fatigue task
Time frame: Before to after approximately 8 hours of sleep with and without acoustic stimulation
Changes in bandwidth of of 0.5-30 Hz of high-density electroencephalography (hdEEG)
Assessment of resting state and task-related hdEEG
Time frame: Before to after approximately 8 hours of sleep with and without acoustic stimulation
Hypnogram
assessed by sleep staging of hdEEG data
Time frame: Over approximately 8 hours of sleep with and without acoustic stimulation
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