Efficacy and Safety of Painless 5-aminolevulinic Acid Photodynamic Therapy for Moderate and Severe Acne Vulgaris

Inclusion Criteria: * Clinical diagnosed with moderate to severe acne * Male and female patients of age between 18-40 years old * All patients read the instructions of the subject, willing to follow the program requirements * No other topical treatment received within 2 weeks prior to enrollment * No systemic treatment was given within 4 weeks prior to enrollment * Patients were unsuitable for other treatments for various reasons and signed informed consent when they had informed other alternatives and agreed to take pictures of the lesion Exclusion Criteria: * Those who did not complete the informed consent * The lesions belongs to any of the following conditions: There is damage and inflammation, which may lead to the drug entering the open wound * Patients with skin photoallergic diseases, porphyria * Known to have a history of allergies to test drugs (porphyrins) and their chemically similar drugs * Patients with other obvious diseases that may affect the evaluation of efficacy * Scars or patients with a tendency to form scars * Known to have severe immune dysfunction, or long-term use of glucocorticoids and immunosuppressants * Severe heart, liver, kidney disease; with hereditary or acquired coagulopathy * Those with severe neurological, psychiatric or endocrine diseases * Women who are pregnant, breast-feeding or using inappropriate contraceptives -Those with a history of drug abuse; those who have participated in other drug clinical trials within 4 weeks before treatment