In daily practice, several scales are used to evaluate patients with small vessel diseases of the brain (SVD). However, these scales exclude key symptoms such as apathy and mood disorders observed in SVD. Furthermore, the use of a combination of scales does not allow neither a very sensitive assessment of clinical changes, neither an overall assessment of a patient's outcome. Moreover, there is no scale dedicated to cognitive, emotional and behavioural complaints in patients with SVD. These patients are evaluated with scales used in neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. These are scales that have been developed in the elderly and they are not sensitive to minor complaints. It is needful to develop scales adapted to patients with SVD in order to understand the consequences of the disease symptoms on their daily life at inclusion and during follow-up.
Study Type
OBSERVATIONAL
Enrollment
150
Lariboisiere hospital
Paris, France
RECRUITINGDevelop a Global Clinical Severity Scale in Patients with cerebral SVD
The primary outcome is to develop this scale, thus precise definition of the scale is not available
Time frame: 3 years post-inclusion
Internal validity of each scale
To analyze correlations between items, scale structure, o floor and ceiling effects and profiles of missing data
Time frame: 3 years post-inclusion
Intra evaluator reliability
Time frame: 3 years post-inclusion
Inter-evaluator reliability
Time frame: 3 years post-inclusion
Scale validity
Time frame: 3 years post-inclusion
Scale sensitivity to change
To determine clinically important minimal difference.
Time frame: 3 years post-inclusion
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