Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine

Inclusion Criteria: * Men or women, age 18 or older at screening, who have used electronic cigarettes and/or smoked at least 5 cigarettes per day in the past 30 days * Saliva cotinine of \> 50 ng/mL at screening * No clinically significant findings on the physical examination at screening * Ability to communicate well with the investigator and to understand and comply with the requirements of the study * Women of child-bearing age: willingness of using a reliable contraception method during the study * Signed informed consent Exclusion Criteria: * Known hypersensitivity/allergy to a content of the e-liquid * Pregnancy or breast feeding * BMI \< 18 or \> 28 kg/m2 at screening * History or clinical evidence of alcoholism or drug abuse within the 3-year period prior to screening * Loss of ≥ 250 ml of blood within 3 months prior to screening, including blood donation * Treatment with an investigational drug within 30 days prior to screening * Treatment with prescribed or over-the-counter (OTC) medications with potential influence on CYP2A6 function within 1 week prior to screening (with the exception of contraception) * History or clinical evidence of any disease (e.g. gastrointestinal tract-disease) and/or existence of any surgical or medical condition, which in the opinion of the investigator might interfere with the absorption, distribution, metabolism or excretion of the study drugs, or which might increase the risk for toxicity * Legal incapacity or limited legal capacity at screening * Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol