The Association Between the Duration of Acute Kidney Injury and New-onset Chronic Kidney Disease After Cardiac or Thoracic Aortic Surgery

Seoul National University Hospital2,009 enrolled

Overview

The investigators aimed to evaluate the association between the duration and stage of acute kidney injury (AKI) and the development of chronic kidney disease during postoperative three years in patients undergoing cardiac or thoracic aortic surgery.

Postoperative acute kidney injury (AKI) has been investigated as an important contributor to postoperative morbidity and mortality after cardiovascular surgery. Also, temporary worsening of renal function after aortic surgery is associated with higher long-term mortality. Although the associations between AKI and chronic kidney disease (CKD) in medical or other surgical settings were reported, only a few studies evaluated this relationship in patients undergoing cardiac surgery. More specifically, the association of the severity or duration of AKI with the risk of the development of new-onset CKD after cardiac surgery has not been clearly elucidated. It would be important to find predictors of the long-term renal function or risk factors for the development of CKD after cardiac surgery because postoperative management of high-risk patients to develop long-term renal dysfunction may prevent further deterioration in renal function and improve patient prognosis. The investigators aimed to evaluate (1) the long-term renal function after cardiac surgery and (2) the association between the duration and stage of acute kidney injury (AKI) and the development of chronic kidney disease during postoperative three years in patients undergoing cardiac or thoracic aortic surgery.

Study Type

OBSERVATIONAL

Enrollment

2,009

Conditions

Acute Kidney Injury Chronic Kidney Disease, Stage 3 Chronic Kidney Disease, Stage 5

Outcomes

Primary Outcomes

new-onset chronic kidney disease stage 3 or higher or mortality

development of new-onset chronic kidney disease stage 3 or higher or all-cause mortality developed during 3 years after surgery. The new-onset chronic kidney disease was defined by at least two estimated Glomerular Filtration Rate values \<60 ml/min/1.73 m2 separated by an interval of at least three months.

Time frame: during 3 years after surgery

Secondary Outcomes

new-onset chronic kidney disease stage 3 or higher or mortality

development of new-onset chronic kidney disease stage 3 or higher or all-cause mortality developed during 1 year after surgery

Time frame: during 1 year after surgery

new-onset chronic kidney disease stage 3 or higher or mortality

development of new-onset chronic kidney disease stage 3 or higher or all-cause mortality developed during 2 years after surgery

Time frame: during 2 years after surgery

Length of postoperative hospital stay