PET and MRI Imaging of Brain Tumors Using [18F]PARPi

Early Phase 1CompletedNCT04173104

Memorial Sloan Kettering Cancer Center5 enrolled

Overview

This study is to collect data about how 18FPARPi can be used together with PET/positron emission tomography and MRI/magnetic resonance imaging scans to take pictures of brain cancer

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Brain Tumor Brain Cancer

Interventions

PET/MR with [18F]PARPiDIAGNOSTIC_TEST

One PET/MR study (with up to 3 scan times) with \[18F\]PARPi

[18F]PARPiDRUG

Injection of \<100ug of \[18F\]PARPi prior to 1 PET/MR

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with new or suspected recurrent brain tumors (including suspected recurrent brain tumors showing growth from any preceding scan) * Age \>/= 18 years * Minimum at least one brain lesion size \>/= 1.5cm diameter * Scheduled to undergo treatment at MSK * Willingness to sign informed consent * Able to receive intravenous gadolinium contrast per MSK Department of Radiology guidelines Exclusion Criteria: * Any contraindication to 3T MRI (PET/MR scanner is 4.0 Tesla) * Pregnancy or breast-feeding women

Locations (1)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Outcomes

Primary Outcomes

SUVmax measurements

\[18F\]PARPi updtake in lesions will be quantified by standard SUVmax measurements from PET/MR scans

Time frame: Up to 24 weeks

Data from ClinicalTrials.gov

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