Anti-PD-1 Antibody Plus DEB-TACE for BCLC Stage A/B HCC

Inclusion Criteria 1. Age between 18 years and 75 years; 2. ECOG PS 0/1; 3. Patients with histologically- or clinically-confirmed HCC (based on the American Association for the Study of Liver Diseases criteria) that was either BCLC stage A and exceeded the Milan criteria, or BCLC stage B 4. Have not received any anti-tumor systemic treatment in the past 5. No contraindications for the treatment of DEB-TACE and PD-1 inhibitors; 6. Liver function: Child-Pugh score Class A 7. The expected survival of the patient is more than 3 months 8. The following conditions must be met: Platelets ≥ 75 × 10\^9/L White blood cell count (WBC) ≥ 3.0 × 10\^9/L Hemoglobin ≥ 90 g/L Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × upper limit of normal (ULN); total bilirubin (TBIL) ≤ 1.5 × ULN Blood creatinine ≤ 1.5 × ULN PT prolonged ≤ 3 s 9. Adequate bone marrow, cardiac, and renal function 10. Patients must agree to accept postoperative follow-up required by the design of this study; 11. Patients must have the ability to understand and voluntarily sign the informed consent, and must sign an informed consent before starting any specific procedure for the study. Exclusion Criteria 1. History of other malignancies； 2. In combined with severe heart, lung, kidney or other important organ dysfunction, or combined with serious infection or other serious associated diseases, that cannot tolerate treatment (\> CTCAE Version 5.0 adverse events of grade 2)； 3. With uncontrolled hepatitis B (HBV-DNA\>2000 IU/ml and elevated ALT). 4. Spontaneous rupture and bleeding of HCC 5. Hepatic tumor burden \>50% total liver volume 6. Complete occlusion of the portal vein 7. Evidence of a bleeding diathesis or coagulopathy, active infections, and autoimmune disease 8. Recurrent disease after surgery within the last 5 years 9. History of organ transplantation or plan to have liver transplantation; 10. Pregnant women, nursing mothers. 11. Patients have other factors that may interfere with patient enrollment and assessment results. 12. Refuse follow-up as required by this study protocol and refuse to sign informed consent.