Gastroschisis is a rare congenital malformation consisting in a right para-umbilical defect of the abdominal wall leading to an evisceration of the abdominal content. About 25% of the cases are associated with intestinal malformation, leading to an increase in peri-natal morbidity and mortality. No prospective study has been able to definitely describe predictive factors for complicated gastroschisis on prenatal ultrasound examinations. The aim of the current study is to prospectively look for US prenatal features predictive of complicated gastroschisis, on a national multicentric cohort. Patients will be included during the 22 weeks of amenorrhea (WA) ultrasound examination, and pre- and postnatal clinical data will be recorded up to the 6th months of the child. Data will then be analysed and compared in the groups of simple or complicated gastroschisis, in order to define pre-natal prognostic factors, to correlate them with specific prognosis, and to might better determine specific strategies for better care of these patients.
Study Type
OBSERVATIONAL
Enrollment
200
University Hospital of Amiens
Amiens, France
NOT_YET_RECRUITINGUniversity Hospital of Angers
Angers, France
RECRUITINGUniversity Hospital of Besançon
Besançon, France
RECRUITINGUniversity Hospital of Bordeaux
Bordeaux, France
RECRUITINGUniversity Hospital of Brest
Brest, France
RECRUITINGUniversity Hospital of Caen
Caen, France
RECRUITINGUniversity Hospital of Bicêtre
Clamart, France
RECRUITINGUniversity Hospital of Clermont-Ferrand
Clermont-Ferrand, France
RECRUITINGUniversity Hospital of Dijon
Dijon, France
NOT_YET_RECRUITINGUniversity Hospital of Grenoble
Grenoble, France
RECRUITING...and 26 more locations
Evaluation of the collar diameter/abdominal circumference ratio as a predictive factor of complex gastroschisis.
The measures of the collar diameter/abdominal circumference ratio on antenatal ultrasound examination will be evaluated as predictive factor of complex gastroschisis
Time frame: 2,5 years
Evaluation of antenatal ultrasound in predictive diagnosis of complex gastroschisis
Identify other predictive ultrasound factors of complex gastroschisis among the different ultrasound measurements, such as gastric dilatation, maximum diameter of the intraabdominal loop, ...
Time frame: 2,5 years
Composite predictive criterion of complex gastroschisis
Define the existence of a composite predictive criterion of complex gastroschisis that incorporates all or several predictive ultrasound factors
Time frame: 2,5 years
Composite predictive criterion of complex gastroschisis by MRI
Perform the same measurements as for outcome 3 by MRI
Time frame: 2,5 years
Research risk factors in the mother
Search for risk factors for complex gastroschisis from medical examination of the mother (age, tobacco, drugs, body mass index, exposure to chemicals)
Time frame: 2,5 years
Propose a decision algorithm for prenatal management of these patients
Based on identified risk factors
Time frame: 2,5 years
Measure the impact of complex gastroschisis on follow-up until 6 months of children
Use of different parameters (clinical assessment at 6 months, medical history) to evaluate the impact of complex gastroschisis on children at 6 months
Time frame: 6 months of child's life
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