One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized by transient postoperative mutism, dysarthria, behavioral, and affective disorders, as well as motor disorders. PFS is thought to be related to axonal lesions. The long-term consequences on the cognitive and psychosocial sphere of PFS have been widely documented. On the other hand, the literature concerning the consequences of this syndrome on language is much restricted. Beyond the language, the role of cerebellum would be central in cognition, some authors even comparing it to a great "conductor" who would underlie the learning of most motor and cognitive automatisms.
The physiopathology and the anatomo-functional correlates of motor, cognitive, and language functions after surgery of PF tumors are still rare and little known. The objective of this study is to analyze them via morphometric MRI analysis and functional and structural connectivity in children away from PF surgery, coupled with clinical data analysis.
Study Type
OBSERVATIONAL
Enrollment
145
list of the tests: Box and Blocks test, Nine Hole Peg test, walkway GAITRite, EXALang tests, NEPSY II subtests, BRIEF, FEE, WISC 5 tests
CHU Angers
Angers, France
RECRUITINGHôpital Necker
Paris, France
NOT_YET_RECRUITINGInstitut Curie
Paris, France
NOT_YET_RECRUITINGHôpitaux Saint-Maurice
Saint-Maurice, France
NOT_YET_RECRUITINGGustave Roussy
Villejuif, France
NOT_YET_RECRUITINGStructural and functional connectives in brain MRI
Review and compare, in MRI, the structural and functional cerebellar-hemispheric connectives. The primary endpoint the analysis of fMRI brain mapping in accordance to the relations with the motor functions (balance and dexterity), cognitive, behavioral/social cognition and language after treatment for a child's posterior fossa tumor (with or without posterior fossa syndrome) and, in comparison with matched control group on age, sex and level study. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters.
Time frame: One day
Dexterity with Box and Blocks test
Evaluation of the dexterity with Box and Blocks test (number of displaced blocks with each hand).
Time frame: One day
Dexterity with Nine Hole Peg test
Evaluation of the dexterity with Nine Hole Peg test (sum of time of realization of the test in seconds and number of displaced pegs).
Time frame: One day
The balance and the walk
Evaluation of the balance and the walk with the walkway (time in seconds for the completion of the walkway).
Time frame: One day
Language functions
Evaluation of the language functions with the EXALang tests (lexicology, phonology, oral expression, oral understand, reading ...).
Time frame: One day
Social cognition functions and the cognitive function: recognition of the affects
Evaluation with the NEPSY II subtests (total score of 35).
Time frame: One day
Social cognition functions and the cognitive function: behavioural executive functions
Evaluation with the BRIEF test (86 items for parents).
Time frame: One day
Social cognition functions and the cognitive function: flexibility
Evaluation with the FEE test (completion time and number of errors).
Time frame: One day
Social cognition functions and the cognitive function: perceptual and verbal reasoning
Evaluation with the WISC V test (number of correct answers).
Time frame: One day
Patients characteristics
Age, sociodemographics, personal and cancer history.
Time frame: One day
Quality of life of patients: PedsQL questionnaire
Comparison of score of Quality of Life questionnaire (PedsQL 4.0: Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales) between the four groups of the study. The Quality of Life questionnaire PedsQL 4.0 is composed of 23 items comprising 4 dimensions. Items are reversed scored and linearly transformed to a 0-100 scale. In order to get a total score we must sum all the items scores over the number of items answered on all the scales. If more than 50% of the items in the scale are missing, the scale scores should not be computed.
Time frame: One day
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