Lung Ultrasound in Children With Severe Malaria

Inclusion Criteria: * Children aged between 1 and 14 years; * Admitted for confirmed severe malaria (i.e. positive peripheral blood slide for malaria parasite and/or positive rapid diagnostic test for malaria in combination with one or more clinical or laboratory severity criteria detailed below). * Informed consent signed Clinical features of severe malaria * Cerebral malaria; A Glasgow Coma Scale of less than 11 or a Blantyre coma scale less than 3 in preverbal children * Respiratory distress (costal indrawing, use of accessory muscles, nasal flaring, deep breathing or severe tachypnea (respiratory rate \> upper normal limit for age) * Jaundice (visible jaundice) * Circulatory collapse or shock: age \<12 systolic blood pressure \< 70mm Hg; age \> 12 systolic blood pressure \<80mm Hg with cool extremities or capillary refill time \>3 seconds * Spontaneous bleeding * Multiple generalized convulsions: more than two episodes within 24h * Prostration, i.e. generalized weakness so that the patient is unable to sit, stand or walk without assistance Laboratory features and other findings * Metabolic acidosis (venous plasma bicarbonate \< 15mmol/l or base excess \< -2.2mEq/L) * Severe anaemia (age \<12: hematocrit \< 15% or haemoglobin \< 5g/dl; age\>12: hematocrit \< 20% or hemoglobin \< 7 g /dl) * Hypoglycaemia (\< 2.2mmol/l or \< 40mg/dl) * Hyperparasitaemia defined as \> 10% * Hyperlactataemia (venous lactate \< 5 mmol/L) * Kidney dysfunction (blood urea \>20mmol/L) Exclusion Criteria: * Co-morbidity which, in the judgement of the investigator or treating physician, would place the subject at undue risk or interfere with the patient's treatment or results of the study. E.g. immediate transfer needed.