The study will be conducted on 60 children suffering from status epilepticus who will be admitted to Pediatric Neurology Unit and Pediatric ICU of Tanta Hospital University.
The aim of this work is to compare the efficacy of Levetireacetam and Phenytoin in management of pediatric status epilepticus.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
The levetiracetam dose is 20- 40 mg/kg by intravenous infusion over 15 minute, a rate of 2-5 mg/kg/minute diluted in 100 ml with 0.9% sodium chloride as a single dose.
Phenytoin dose is 20-40 mg/kg/min by intravenous infusion over 30 minute, diluted with 0.9% sodium chloride to a maximum concentration of 10 mg/ml.
Tanta University, Faculty of Medicine
Tanta, Gharbia Governorate, Egypt
RECRUITINGcessation of convulsion
seizure control based on stoppage of tonic and clonic movements and absence of epileptic activity in EEG
Time frame: 30 minutes
bradycardia
monitoring of heart rate
Time frame: 6 hours
respiratory depression
monitoring of respiratory rate
Time frame: 6 hours
decreased conscious level
Glasgow Coma Score
Time frame: 6 hours
hypotension
measurement of blood pressure
Time frame: 6 hours
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