This investigator initiated, prospective, observational, single-center study is designed to assess whether dynamic monitors of cardiac function such as stroke volume variation (SVV) that have been shown to predict volume responsiveness differ in clinical utility between patients with and without diastolic dysfunction.
This investigator initiated, prospective, observational, single-center study is designed to assess whether dynamic monitors of cardiac function, such as stroke volume variation (SVV), that have been shown to predict volume responsiveness differ in clinical utility between patients with and without diastolic dysfunction. Specific Aims: * Determine the threshold for the predictive response of SVV with respect to increasing cardiac output for patients with and without diastolic dysfunction. * Compare the trans thoracic ultrasound assessment of left ventricular diastolic function before and after the induction of general anesthesia.
Study Type
OBSERVATIONAL
Enrollment
120
Ultrasound examination of cardiac function before and after induction of general anesthesia.
Intravenous fluids will be administered as a bolus in response to standard clinical indications
UC Davis Health System
Sacramento, California, United States
Impact of diastolic function on the response threshold for stroke volume variation (SVV) as a predictor of the cardiac output response to fluid administration.
The sensitivity of SVV as a predictor of the change in cardiac output in response to IV fluid administration will be determined by analysis of the Receiver Operator Characteristic (ROC) curves for each of the patient groups as distinguished by their pre-induction assessment of diastolic left ventricular function
Time frame: Through study completion, an average of 1 year
Grade assessment of diastolic function
Transthoracic ultrasound will be performed before and after the induction of general anesthesia to assess left ventricular diastolic function. Measurements of trans-mitral flow velocities and tissue Doppler velocities will be used to establish the grade of left ventricular diastolic function. The reproducibility of this measurement before and after the induction of anesthesia has ramifications for intra-operative measurement of diastolic function.
Time frame: Through study completion, an average of 1 year
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