The purpose of this study is to investigate Thiol-disulfide balance in patients with cervical preinvasive lesions
To date various oxidative stress paramaters were studied in patients with cervical preinvasive lesions, however dynamic thiol disulfide hemostasis has not been previously investigated. The thiol-disulfide balance in the circulation will be measured by the automated system created by Erel \& Neselioglu(1). References 1- Erel O, Neselioglu S. A novel and automated assay for thiol/ disulphide homeostasis. Clin Biochem 2014;47:326-32. doi:10.1016/ j.clinbiochem.2014.09.026.
Study Type
OBSERVATIONAL
Enrollment
300
Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry
Aforementioned oxidative stress markers will be measured via Cobas c501(Roche Diagnostics, Indianapolis, IN, USA) used with sphectrophotometry
Mugla Sıtkı Kocman University Faculty of Medicine
Muğla, Turkey (Türkiye)
serum native thiol level
serum native thiol level in μmol/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
serum disulphide level
serum disulphide level in μmol/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
serum total thiol level
serum total thiol level in μmol/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
the disulphide/native thiol ratio
the disulphide/native thiol ratio X (100 )
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
disulphide/total thiol ratio
disulphide/total thiol ratio X (100 )
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
native thiol/total thiol ratio
native thiol/total thiol ratio X (100 )
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
total antioxidant capacity (TAC)
TAC in mmol trolox equivalent/L
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
total oxidant capacity (TOC)
TOC in mmol H2O2 equivalent/L
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Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)
Oxidative stress index (OSI)
OSI in mmol trolox/L.
Time frame: baseline (preoperative in the morning or preprandial for healthy volunteers)