Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic Shock

Inclusion Criteria: * The patient or their legal representative must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * The patient has septic shock according to the SEPSIS-3 definition in the 24 hours preceding inclusion, regardless of the source of infection * Patient having already received a first dose of amikacin in the 22 preceding hours * Patient with an expectation of receiving at least 2 doses of amikacin * Patient with available amikacin therapeutic drug monitoring Exclusion Criteria: * The subject is participating in an interventional study that could influence the primary outcome, or is in a period of exclusion determined by a previous study * The patient is pregnant, parturient or breastfeeding * Patient has a contra-indication or an allergy to treatment by amikacin * Patient is not expected to survive beyond 48 hours