Patient with myocardial infarction with non-obstructive coronary arteries and takotsubo syndrome often have high levels of stress and anxiety. At present there are no treatment alternatives in this group of patients. Previously, cognitive behavioral therapy (CBT), primarily aiming at relieving stress, has been shown to decrease morbidity in patient with myocardial infarction with obstructive coronary arteries. The present open randomized study aims to decrease stress and anxiety in patients with myocardial infarction with non-obstructive coronary arteries and takotsubo syndrome by an internet-based CBT focusing on stress and anxiety.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
64
A nine step intervention including internet-based feedback by psychologists
Södersjukhuset
Stockholm, Sweden
RECRUITINGSelf-rated stress as determined by Perceived Stress Scale 14 (PSS-14)
Normalisation of PSS-14 (\<25 on a scale 0-56 with high numbers indicating increased stress)
Time frame: 12-14 weeks after the acute event
Self-rated anxiety as determined by Hospital Anxiety and Depression Scale (HADS)
Normalisation of HADS-A (\<8 on a scale 0-21 with high numbers indicating increased anxiety)
Time frame: 12-14 weeks after the acute event
Self-rated stress as determined by Perceived Stress Scale 14 (PSS-14)
PSS-14 (\<25 on a scale 0-56 with high numbers indicating increased stress)
Time frame: 10, 20 and 50 weeks after randomisation
Self-rated anxiety as determined by Hospital Anxiety and Depression Scale (HADS)
HADS-A (\<8 on a scale 0-21 with high numbers indicating increased anxiety)
Time frame: 10, 20 and 50 weeks after randomisation
Self-rated quality-of-life determined by Research ANd Development-36 (RAND-36)
RAND-36: 0-100 with high numbers indicating better quality-of-life
Time frame: 10, 20 and 50 weeks after randomisation
Self-rated cardiac anxiety determined by Cardiac Anxiety Questionnaire (CAQ)
CAQ: 0-72 with high numbers indicating increased cardiac anxiety
Time frame: 10, 20 and 50 weeks after randomisation
Self-rated post-traumatic symptoms determined by Impact of Event Scale-6 (IES-6)
IES-6: 0-30 with high numbers indicating increased post-traumatic symptoms
Time frame: 10, 20 and 50 weeks after randomisation
Sick leave
Self-reported total number of days
Time frame: 10, 20 and 50 weeks after randomisation
Health-care visits
Self-reported total number of visits
Time frame: 10, 20 and 50 weeks after randomisation
Cortisol in hair
Hair cortisol will be determined by RIA-technique in pg/mg
Time frame: 10 weeks after randomisation
Physiological recovery after stress determined by Heart Rate Variability (HRV)
HRV will be measured by time and frequency domains and by non-linear methods
Time frame: 10 weeks after randomisation
Physiological recovery after stress determined by salivary cortisol
Salivary cortisol will be determined by RIA-technique in pg/mg
Time frame: 10 weeks after randomisation
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