The purpose of this study is to investigate the diagnostic performance of quantitative ultrasound imaging parameter for the assessment of hepatic steatosis in patients with non-alcoholic fatty liver disease using magnetic resonance imaging proton density fat fraction (MRI-PDFF) and MR spectroscopy as the reference standard.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
124
Quantitative ultrasound imaging parameters (QUS) are analyzed to evaluate hepatic steatosis
Seoul National University Hospital
Seoul, South Korea
Correlation between quantitative US imaging parameter (QUS) and MR fat fraction
reference standard: MR spectroscopy or MRI-proton density fat fraction value
Time frame: 3 months
Diagnostic performance of QUS to detect mild fatty liver and moderate fatty liver
reference standard: MR fat fraction
Time frame: 3 months
Correlation between S-shearwave elastography and MR elastography
Reference standard: liver stiffness at MR elastography, using Pearson's correlation analysis or Spearman rank correlation analysis
Time frame: 3 months
Intra-observer agreement of quantitative ultrasound imaging parameter
intraclass correlation coefficient (ICC)
Time frame: same 1 day
Development and validation of deep learning model for prediction of hepatic steatosis
ROC analysis and C-index for deep learning model for prediction of hepatic steatosis
Time frame: 1 month
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