Acute Olanzapine and Lipid Response

Inclusion Criteria: * Men and women, aged 18 to 60 years * Body mass index (BMI) 20 to 40 kg/m2 * Hemoglobin in the normal range. * Normal glucose tolerance in response to a 75 gram, 2-hr oral glucose tolerance test * Women of reproductive age should be on contraception (oral contraceptive pill or intra-uterine device/coil) for at least 2 months prior to and after the study. Anyone with a positive urine pregnancy test (carried out at screening and the day before each kinetic study) will be excluded. Exclusion Criteria: * Any volunteer with evidence of prolonged corrected QT interval (\>470 ms in males and \>450ms in females) * Any volunteer with morbid obesity (BMI\>40 or BMI\>30 with any obesity related medical complication such as diabetes, hypertension or coronary disease) * Any history of a myocardial infarction or clinically significant, active, cardiovascular history including a history of arrhythmia's or conduction delays on echocardiogram, unstable angina, or decompensated heart failure * Study participant with a history of hepatic disease that has been active within the previous two years. * Any current or previous history of biliary disease (including gall stones, biliary atresia and cholecystitis) or pancreatitis. * Any current or previous history of endocrine disease, dyslipidemia or malignancy * Any significant active (over the past 12 months) disease of the gastrointestinal, pulmonary, neurological, renal (Cr \> 1.5 mg/dL) genitourinary, hematological systems, or has severe uncontrolled treated or untreated hyper/ hypotension (sitting diastolic BP \> 100 or systolic \> 180 or systolic BP\<100) or proliferative retinopathy * Use of immunosuppressive agents at any time during the study * Allergy to any study medication * Pregnancy (as ascertained by urinary human chorionic gonadotropin at screening and the day before each study visit) or breastfeeding * Fasting blood glucose \> 6.0 mmol/l or known diabetes. * Any laboratory values: aspartate aminotransferase \> 2x upper limit of normal (ULN); alanine transaminase \>2x ULN thyroid stimulating hormone \> 6 mU/l * Current addiction to alcohol or substances of abuse as determined by the investigator or of any mental illness. * Mental incapacity, unwillingness or language barrier precluding adequate understanding or cooperation * Taking any regular prescription or non-prescription medications at the time of the study. Occasional use of medications such as acetaminophen or Tylenol 1 or any use of natural health products may be permitted at the discretion of the investigator. * Will not donate blood three months prior to and three months post study procedures * Hemoglobin below the reference range (less than 130 g/l for males and 120 g/l for females) based on blood tests at screening and on the day before the kinetic study * Hematocrit below the reference range (less than 0.38 for males and 0.37 for females) based on blood tests at screening and on the day before the kinetic study * Soy allergy (component of high-fat drink)