This study will evaluate the incidence of allergic manifestations (the first of which is atopic dermatitis) and infectious diseases in children fed with an infant formula under real conditions of use.
The primary objective of the study is to evaluate the cumulative incidence of atopic dermatitis in healthy infants at risk for dysbiosis at 12 months of age and to identify factors associated with the presence of atopic dermatitis.
Study Type
OBSERVATIONAL
Enrollment
334
Healthy full-term infants fed on an infant formula marketed on the French market
Medical Office
Taverny, France
Cumulative incidence of atopic dermatitis in the infants included in the study
Number of episodes of dermatitis reported during the 12 months of follow-up, and objectified by a SCORAD score \> 0.
Time frame: 12 months
Atopic dermatitis
Cumulative incidence of episodes of moderate atopic dermatitis (SCORAD score of 25 to 50) or severe episodes (SCORAD score\> 50)
Time frame: 3, 6 and 12 months
Gastrointestinal tolerance
* Frequency, consistency, color and quantity of stool (Amsterdam scale), * Frequency and intensity of regurgitations (adapted score of Vandenplas), * Frequency and intensity of gas / bloating, colic, unexplained crying
Time frame: 3, 6 and 12 months
Height
Growth in term of height
Time frame: 3, 6 and 12 months
Weight
Growth in term of weight
Time frame: 3, 6 and 12 months
Cranial perimeter
Growth in terme of cranial perimeter
Time frame: 3, 6 and 12 months
Observance
% of children who consumed the formula prescribed by the doctor at the previous visit
Time frame: 3, 6 and 12 months
Consumption
Number of days of consumption during the previous period.
Time frame: 3, 6 and 12 months
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Satisfaction with Likert scale
5-level Likert scale filled in by the doctor and by parents
Time frame: 3, 6 and 12 months
Cumulative incidence of allergic manifestations
Cumulative number since the inclusion of episodes of: * atopic dermatitis, * eczema, * wheezing, * allergic rhinitis
Time frame: 3, 6 and 12 months
Cumulative incidence of infections
Cumulative number since the inclusion of episodes of: * Infection of the upper respiratory tract, * Infection of the lower respiratory tract, * Gastrointestinal infections, * pyelonephritis,
Time frame: 3, 6 and 12 months