Ultrasound-Based Renal Sympathetic Denervation as Adjunctive Upstream Therapy During Atrial Fibrillation Ablation

Inclusion Criteria: * Age ≥ 18 * Planned for a first-ever AF ablation procedure (paroxysmal or persistent); (prior to randomization, a technically successful AF ablation procedure, defined as involving pulmonary vein isolation, as well as bidirectional block of any attempted anatomic lesion sets such as cavotricuspid isthmus line, roofline, mitral line and superior vena cava isolation must have been completed) * History of hypertension and either: * Documented history of SBP ≥ 160 or DBP ≥ 100 (Stage III), or * Receiving ≥ 1 antihypertensive medication * Willingness to adhere to study restrictions and comply with all post-procedural follow-up requirements Exclusion Criteria: (if any of the following are YES, subject is not eligible) * Long-standing persistent AF (\> 12 months) * Individual with valvular AF or AF due to a reversible cause * Prior left atrial catheter or surgical ablation for an atrial arrhythmia (before this index procedure) * Prior left atrial surgery (such as mitral valve surgery or surgical ASD repair) * Prior treatment with other devices for hypertension including but not limited to ROX Coupler, Mobius stent and/or the CVRx barostimulator device * NYHA Class IV Congestive Heart Failure * Individual has renal artery anatomy that is ineligible for treatment (as determined by intra-procedural renal angiography). This includes: * Main renal artery diameter \< 3.0 mm or \> 8.0 mm * Main renal artery length \< 20 mm * Presence of renal artery stenosis of any origin ≥ 30% * Accessory arteries with diameter ≥ 2 mm and \< 3.0 mm * Calcification in renal arteries at locations where energy is to be delivered * Prior renal denervation procedure * Presence of abnormal kidney tumors * Renal artery aneurysm * Pre-existing renal stent or history of renal artery angioplasty * Pre-existing aortic stent or history of aortic aneurysm * Fibromuscular disease of the renal arteries * Iliac/femoral artery stenosis precluding insertion of the Paradise Catheter * Individual has an estimated glomerular filtration rate (eGFR) of less than 40mL/min/1.73m2 * Inability to undergo AF catheter ablation (e.g., presence of left atrial thrombus, contraindication to all anticoagulation) * Individual with known allergy to contrast medium not amenable to treatment * Life expectancy of \< 1 year for any medical condition * Individual has experienced a myocardial infarction, unstable angina, cerebrovascular accident, or heart failure admission within 3 months of screening visit * Documented history of chronic active inflammatory bowel disorders such as Crohn's disease or ulcerative colitis * Female participants who are pregnant or nursing * Individual has known secondary hypertension * Individual has a single functioning kidney (either congenitally or iatrogenically) * Individual has a known, unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or would be unlikely or unable to comply with study follow-up requirements * Patients concurrently enrolled in any other investigational drug or device trial that would interfere with the conduction of this trial