Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT

Seoul National University Hospital72 enrolled

Overview

The aim of this study is to evaluate difference in the rate of recovery of intestinal motility according to different ascites replacement strategy after living donor liver transplantation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Living Donor Liver Transplantation

Interventions

Ascites replacement with albumin and hartmann's solutionDRUG

Combined strategy for ascites replacement * 30% of ascites: replacement with 5% albumin * 40% of ascites: replacement with Hartmann's solution

Ascites replacement with hartmann's solutionDRUG

Hartmann's solution only strategy for ascites replacement \- 70% of ascites: replacement with Hartmann's solution

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (19 years or older) * Elective living donor liver transplantation Exclusion Criteria: * Previous abdominal surgery * Renal failure requiring renal replacement therapy * Contraindications for 5% albumin use 1. Condition with potential risk caused by increased circulating plasma (heart failure, renal failure combined with oliguria, pulmonary edema) 2. Hemolytic anemia * Contraindications for Hartmann solution 1. Progressive lactic acidosis 2. Hypervolemia 3. Hypernatremia

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Time to 1st flatus

Interval between SICU admission and 1st flatus

Time frame: within 4 weeks

Time to 1st diet

Interval between SICU admission and 1st diet

Time frame: within 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.