This is a multi-center prospective case control study aiming to compare different methods of risk stratification models in predicting the risk of gastric cancer development.
The case control study would compare which type of assessment (Endoscopic / histological) is more accurate in predicting the risk of gastric cancer development. The risk factor assessment would be based on the following criteria. Endoscopic assessment: 1. Atrophic gastritis, based on Kimura Takemoto Classification 2. Kyoto classification of gastritis 3. Intestinal metaplasia, based on Endoscopic Mapping and Grading of Intestinal Metaplasia (EGGIM) Histological assessment (Based on random biopsies) 1\. Operative Links on Gastritis Assessment 2. Operative Links on Gastric Intestinal Metaplasia
Study Type
OBSERVATIONAL
Enrollment
400
Gastroscopy would be performed to assess the degree of atrophic gastritis and intestinal metaplasia. In addition, four random biopsies would be taken in the stomach for histological assessment of AG and IM
Prince of Wales Hospital
Hong Kong, Hong Kong
RECRUITINGOsaka International Cancer Institute
Osaka, Japan
NOT_YET_RECRUITINGChangi General Hospital
Singapore, Singapore
NOT_YET_RECRUITINGEndoscopic grading of atrophic gastritis (Kimura Takemoto Classification)
Endoscopic description of severity of gastric atrophy
Time frame: Cross sectional study, day 0
Endoscopic grading of intestinal metaplasia (EGGIM)
Endoscopic mapping of degree of intestinal metaplasia
Time frame: Cross sectional study, day 0
Kyoto classification of gastritis
Descriptive findings of gastritis
Time frame: Cross sectional study, day 0
Operative links on gastritis assessment (OLGA)
Biopsy based risk stratification panel based on severity of atrophic gastritis
Time frame: Cross sectional study, day 0
Operative links on gastric intestinal metaplasia (OLGIM)
Biopsy based risk stratification panel based on severity of intestinal metaplasia
Time frame: Cross sectional study, day 0
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King Chulalongkorn Memorial Hospital and Chulalongkorn University
Bangkok, Thailand
NOT_YET_RECRUITING