This is an explorative, proof-of-concept study exploring the potential therapeutic role of a Liraglutide-based weight loss regimen versus standard CPAP or the combination of both on metabolic parameters, blood pressure, endothelial function, coronary artery calcification, vascular inflammation and apnea/hypopnea index in non-diabetic patients with moderate to severe obstructive sleep apnea
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
GLP-1 analogue treatment in combination with advice on diet and physical exercise
Gold standard treatment for obstructive sleep apnea
Combination of both treatments
St Vincent's University Hospital
Dublin, Dublin 4, Ireland
Insulin resistance
Improvement in insulin resistance defined by HOMA-IR
Time frame: 6 months
Weight
Change in body mass index
Time frame: 6 months
Glucose tolerance
Change in glucose tolerance measured by oral glucose tolerance test
Time frame: 6 months
OSA Severity
Change in apnea/hypopnea index as per polysomnography
Time frame: 6 months
Blood pressure
Change in 24-hour blood pressure
Time frame: 6 months
Endothelial function
Change in microvascular endothelial function measured by EndoPat
Time frame: 6 months
Coronary artery calcification
Change in coronary artery calcification score determined by Coronary artery CT
Time frame: 6 months
Vascular inflammation
Change in vascular inflammation determined via FDG-PET scan
Time frame: 6 months
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