Immunopathologic Profiles and Blood Biomarkers in Patients With IPF

University of Aarhus100 enrolled

Overview

Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in patients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in patients with IPF compared with other interstitial lung diseases. Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

Examination of expression of PD-L1, PD-L2, Beta- catenin, B-cell follicles and Tenascin- C in cryobiopsies from the lungs inpatients with IPF compared with other interstitial lung diseases. Examination of anti HSP 70, p-ANCA, c-ANCA, CD4+/CD28- and CD8+/CD28- cells in blood samples in patients with IPF compared with other interstitial lung diseases. Compare the above mentioned findings with changes in pulmonary function tests, 6 minute walking test, exacerbation and mortality over a 2 year follow-up period.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Idiopathic Pulmonary Fibrosis

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients suspected of having an ILD who are having cryobiopsies performed Exclusion Criteria: * BMI \> 35 * DLCO \< 35% * FVC \< 45% * Pulmonary hypertension * Cardiac or other severe comorbidity that will increase the risk of complications

Locations (1)

Aarhus University Hospital, Department of Respiratory Diseases and Allergy

Aarhus, Denmark

Outcomes

Primary Outcomes

PD-L1

Expression of PD-L1 in the epithelial cells in lungs

Time frame: At diagnosis

Data from ClinicalTrials.gov

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