Association Between Light Spectrum and Survival After Cataract Surgery

University of Pittsburgh10,192 enrolled

Overview

This study was a retrospective observational cohort analysis of subjects aged 65 years and older, who underwent bilateral cataract surgery within a single (15 hospital) healthcare system, to determine the association between type (conventional or blue-light filtering) of implanted intraocular lens and survival.

Study Type

OBSERVATIONAL

Enrollment

10,192

Conditions

Interventions

Blue-light filtering intraocular lensDEVICE

Bilateral implantation of blue light-blocking intraocular lens

Conventional intraocular lensDEVICE

Bilateral implantation of conventional intraocular lens

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The study population consisted of all adult patients (at least 65 years) who underwent bilateral cataract surgery between January 01, 2012 and January 01, 2018 within the University of Pittsburgh Medical Center (UPMC) healthcare system. To be considered bilateral and concomitant, cataract surgery had to be performed on both the left and the right eye within a 365-day period. Exclusion Criteria: * We excluded patients undergoing unilateral cataract surgery, surgery to replace or repair a previously implanted IOL, or bilateral implantation with one Blue-IOL and one Natural-IOL (i.e., mixed IOL transmission properties).

Locations (1)

UPMC-Presbyterian Hospital

Pittsburgh, Pennsylvania, United States

Outcomes

Primary Outcomes

All-cause mortality

The primary outcome was all-cause mortality. Mortality was identified based on the Social Security Death Master File and discharge status. Follow-up started from the day after the initial surgery until the end of the study period or death, whichever occurred first. Time to death was calculated as the number of days from the first cataract surgery to death. Participants who did not have a recorded death were censored on April 30, 2019.

Time frame: From the date of the initial cataract surgery until the date of death or end of the study period (April 30, 2019), whichever occurred first, assessed up to 2,310 days.

Data from ClinicalTrials.gov

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