Use of Fresh Platelet Rich Plasma With Concentrated Leukocytes or Fresh Platelet Rich Plasma Without Concentrated Leukocytes in the Treatment of Knee Cartilage Degeneration: a Randomized Controlled Trial

Inclusion Criteria: Patients with degenerative pathology of the knee cartilage with: 1. Age between 18 and 75 years; 2. Unilateral involvement; 3. Signs and symptoms of degenerative pathology of the cartilage of the knee; 4. Radiographic or MRI signs of degenerative pathology of the cartilage of the knee (Kellgren-Lawrence 1-4 degrees); 5. Hemoglobin\> 11 g / dl; Platelet count\> 150,000 plt / mm3 (recently performed blood count); 6. No clinically significant electrocardiographic alteration (recently performed ECG). 7. Patients' ability and consent to actively participate in clinical follow-up; 8. Signature of informed consent. Exclusion Criteria: 1. Patients undergone to intra-articular infiltration of another substance in the previous 6 months; 2. Patients undergone knee surgery in the previous 12 months; 3. Patients with malignant neoplasms; 4. Patients suffering from rheumatic diseases; 5. Patients suffering from diabetes; 6. Patients with hematologic diseases (coagulopathies); 7. Patients on anti-anticoagulant therapy; 8. Patients suffering from thyroid metabolic disorders; 9. Patients abusing alcoholic beverages, drugs or drugs; 10. Body Mass Index\> 35; 11. Patients who have taken NSAIDs within 3 days before taking blood; 12. Patients with cardiovascular diseases for which the 150 ml blood test would be contraindicated; 13. Patients with a recently performed blood count with Hb values \<11 g / dl and Platelets \<150,000 plt / mm3.