A Clinical Trial to Evaluate the Safety and Immunogenicity of Norovirus Bivalent Vaccine

Inclusion Criteria: * Aged 6 months to 59 years old, can provide legal identification of Chinese population; * Based on medical history and physical examination, determined by the researcher as healthy; * Volunteer legal guardians or trustees have the ability to understand (non-illiterate) research procedures, sign informed consent voluntarily with informed consent, and be able to comply with the requirements of clinical research protocols; * Female subjects of childbearing age were not pregnant at the time of enrollment (negative urine pregnancy test), were not breastfeeding, and had no birth plan within the first 3 months after enrollment; effective contraceptive measures were taken within 2 weeks before enrollment. Exclusion Criteria: * Axillary body temperature before inoculation on the day of entry\> 37.0 ℃; * Congenital malformations or developmental disorders, genetic defects, severe malnutrition, etc .; * Have a history of epilepsy, convulsions or convulsions, or a family history of mental illness; * Those who received immunoenhancement or inhibitor therapy within months (continuous oral or instillation for more than 14 days); * Have been diagnosed with congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia or other autoimmune diseases; * No spleen or spleen function defect caused by any situation; * Severe liver and kidney disease, drug-uncontrollable hypertension (systolic blood pressure\> 140mmHg, diastolic blood pressure\> 90mmHg), diabetic complications, malignant tumors, various acute diseases or chronic attacks of acute diseases; * Have a history of chronic gastrointestinal diseases, diarrhea or other digestive system diseases, and have had gastroenteritis requiring treatment in the past 7 days;. * Have a history of abnormal coagulation function (such as coagulation factor deficiency, coagulopathy); * Have a history of severe allergic reactions to vaccination; are allergic to any component of the test vaccine; * Live attenuated vaccine within14 days; other vaccines received within 7 days; * Participating in other clinical trials in the near future; * The investigator judges other circumstances that are not suitable for participation in this clinical trial. In addition to the general exclusion criteria, specific populations should also adhere to the following exclusion criteria: * Premature birth (delivery before the 37th week of pregnancy), low weight (birth \<2300g) infants under 24 months of age; * History of salvage, birth apnea, or other causes of salvage, neurological damage, severe chronic disease (such as Down syndrome, sickle cell anemia, or neurological disorders) in children under 24 months of age.