First-line Chemotherapy for Recurrent Cervical Cancer

Inclusion Criteria: * Female of 18-75 years old * Eastern Cooperative Oncology Group score 0-1 * Pathological confirmed of uterine cervical adenocarcinoma, squamous carcinoma, or adenosquamous carcinoma, with stage IA1 (with lymph-vascular space invasion) to IVB, which had accepted radical treatment for the purpose of cure * An interval of 3 months or more since the fulfilling of last treatment * At least one measurable lesion defined by Response Evaluation Criteria in Solid Tumors (RECIST) guideline 1.1 * Anticipative survival period of 3 months or more * Lab testing within reference ranges * With appropriate contraception * Provided consents of participating the trial Exclusion Criteria: * With a history of exposure to other antiangiogenic agents * With other malignancies within past 3 years * With vital complications * With uncontrolled hypertension despite of medical treatment * With severe cardiac disease, coagulation disorders, bleeding disorders, vascular diseases, deep venous thrombosis * With brain metastasis * With addiction to psychiatric medications or with mental disorders * With severe open trauma, fracture or major surgery with past 4 weeks * With disorders which would hamper the absorption of oral drugs, or with intestinal perforation or ileus with past 6 months * Urine protein ≥++, or 24 hr urine protein ≥1.0 g * With potential allergy or intolerance to study regimens * Not eligible for the study judged by researchers