Safety and Efficacy of SCM-AGH in Patients With Moderate to Severe Acute Pancreatitis

Inclusion Criteria: 1. \>=19 years of age \[Phase I\] 2. Patient with acute pancreatitis with organ failure which has been determined as severe acute pancreatitis prior to assignment(randomization) (1) Organ failure: 2 points of Modified Marshall Score in one or more of the respiratory system, renal system and cardiovascular system (2) Acute pancreatitis: at least 2 of the following 3 conditions are met 1. Typical abdominal pain indicating acute pancreatitis 2. Increased blood level of pancreatic enzyme (amylase or lipase \>= three times of upper limit of normal) 3. Finding acute pancreatitis in imaging test (contrast enhanced computerized tomography, abdominal magnetic resonance imaging, or abdominal sonography) (3) Severe: at least 1 of following organ failures lasting for \> 48 hours according to the 2012 Atlanta Classification \- Respiratory system: PaO2/FiO2 =\< 300 \- Renal system: Creatinine \>= 1.9 mg/dL * Cardiovascular system: low systolic blood pressure persists despite fluid replacement (SBP \< 90 mmHg. off inotropic support) 3. Patient who or whose representative voluntarily agrees to participate in this study and has given a written informed consent \[Phase II\] 2) Patient with acute pancreatitis with organ failure or CTSI score \>= 4 which has been determined as moderate to severe acute pancreatitis prior to assignment(randomization) 1. Organ failure: 2 points of Modified Marshall Score in one or more of the respiratory system, renal system and cardiovascular system 2. CTSI: Sum of Balthazar grade and Necrosis score. CTSI 1-3: Mild / CTSI 4-6: Moderate / CTSI 7-10: Severe 3. Acute pancreatitis: at least 2 of the following 3 conditions are met a.Typical abdominal pain indicating acute pancreatitis b. Increased blood level of pancreatic enzyme (amylase or lipase \>= three times of upper limit of normal) c. Finding acute pancreatitis in imaging test (contrast enhanced computerized tomography, abdominal magnetic resonance imaging, or abdominal sonography) 4. Moderate to Severe at least 1 of following organ failures lasting according to the 2012 Atlanta Classification - Respiratory system: PaO2/FiO2 =\< 300 - Renal system: Creatinine \>= 1.9 mg/dL * Cardiovascular system: low systolic blood pressure persists despite fluid replacement (SBP \< 90 mmHg. off inotropic support) \[Moderately Severe\] * organ failures lasting for \< 48 hours according to the 2012 Atlanta Classification or CTSI 4-8, \[Severe\] * organ failures lasting for \>= 48 hours according to the 2012 Atlanta Classification 3\) Patient who or whose representative voluntarily agrees to participate in this study and has given a written informed consent Exclusion Criteria: 1. Patient with allergic or hypersensitivity reaction to investigational product, drug of similar class or ingredients (bovine serum, dimethyl sulfoxide) 2. Patient who cannot undergo contrast-enhanced computerized tomography due to allergic reaction to contrast medium 3. Patient past \>72 hours after the onset of organ failure at assignment (randomization) 4. Patient with condition that may develop acute abdominal pain 5. Patient with pancreatitis resulting from trauma, surgery, or neoplasm 6. Patient with unstable ventilation due to underlying disease other than pancreatitis 7. Patient with active infection such as non-pancreatic infection, septicemia, or pneumonia resulting from other disease 8. Patient requiring urgent surgery within 7 days 9. Patient with severe comorbidity (chronic renal disease, hepatic cirrhosis, chronic obstructive lung disease, bronchial asthma, congestive heart failure) 10. Patient with evidence of chronic pancreatitis (recurrent, obstructive and chronic; autoimmune and chronic; marked pancreatic insufficiency such as steatorrhea) 11. Pregnant woman, breastfeeding woman, or woman and man of reproductive potential not willing to use contraceptive measures during the study period 12. Patient who received other investigational product/device within 30 days prior to screening 13. Patient not eligible for study participation in the opinion of the investigator 14. Patient with current or past malignancy