Pain, Inflammation and Opioid Craving

N/ACompletedNCT04190563

Mclean Hospital83 enrolled

Overview

The goal of this study is to investigate the association between response to pain and opioid craving in people with opioid use disorder. In this study, adults with opioid use disorder will be randomized to one of two brief education sessions followed by an assessment of response to pain. Investigators will test the association between response to pain and opioid craving.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Opioid-use Disorder

Interventions

Pain De-CatastrophizingBEHAVIORAL

Experimenter-administered education and skill practice.

Pain EducationBEHAVIORAL

Experimenter-administered education.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18 years or older; * diagnosis of opioid use disorder * chronic pain * ability to read and provide informed consent Exclusion Criteria: * major psychiatric or medical condition that would interfere with participation * current opioid withdrawal * currently receiving opioid analgesic medication for pain * recent history of myocardial infarction or other serious cardiovascular condition * current peripheral neuropathy, active vasculitis or severe peripheral vascular disease * systematic inflammatory or autoimmune disorder * admitted to current treatment episode on an involuntary status

Locations (1)

McLean Hospital

Belmont, Massachusetts, United States

Outcomes

Primary Outcomes

Craving

Investigators will assess opioid craving using the Opioid Craving Scale, a participant-reported measure of opioid craving. This is a continuous measure that is quantified as a total scale score representing an average of the 3 items, with a range from 0-10, with higher scores reflecting more craving. This outcome is the mean score at a single time point, immediately following completion of the intervention.

Time frame: immediately after the intervention

Data from ClinicalTrials.gov

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