The purpose of this research is to study the causes of Sickle Cell kidney disease, as well as to collect and store samples and information about people with Sickle Cell Disease.
Sickle Cell Disease causes kidney injury over time, but it is not clear why some individuals have very significant chronic kidney disease and why some do not. The purpose of this research is to study whether having high levels of 'uric acid,' which is a naturally occurring molecule in the body that may increase kidney injury and systemic inflammation, accelerates the progression of chronic kidney disease over time. Researchers will measure the number of participants that have high uric acid levels at the beginning of the study, as well as the number of participants that develop new high levels throughout the study. The study will also try to determine what causes the high uric acid levels in some patients but not others. The results of this study could help understand kidney injury and uric acid in sickle cell disease better.
Study Type
OBSERVATIONAL
Enrollment
78
No intervention - observational study
Virginia Commonwealth University
Richmond, Virginia, United States
Percentage of participants in the sample with hyperuricemia
(i.e. high uric acid levels) out of all patients with a uric acid level measured at baseline.
Time frame: Baseline
Incidence rate of hyperuricemia per year
Calculate the incidence rate of new cases of hyperuricemia per year in each year of the cohort study
Time frame: Baseline to year 5
The mean rate of change of estimated glomerular filtration rate (eGFR) per year in those with hyperuricemia and those with normouricemia
Determine the mean rate of change of eGFR per year for each group.
Time frame: Baseline to year 5
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