Ventilation Heterogeneity Prior to Lung Resection

N/AUnknownNCT04191174

McMaster University115 enrolled

Overview

This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed tomography (V SPECT) and hyperpolarized 129Xe magnetic resonance imaging (MRI)), in the presence or absence of airway inflammation (assessed by sputum cell counts), in lung cancer patients prior to lung resection surgery.

Study Type

OBSERVATIONAL

Enrollment

115

Conditions

Lung Cancer

Interventions

Hyperpolarized 129Xe MRIOTHER

Hyperpolarized 129Xe MRI to evaluate ventilation heterogeneity

Technegas V SPECTOTHER

Technegas V SPECT to evaluate ventilation heterogeneity

Sputum InductionOTHER

Sputum induction to evaluate luminal cellular inflammation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Undergoing lung resection for lung cancer at St. Joseph's Healthcare (Hamilton, Ontario) in accordance with British Thoracic Society guidelines. * Males and females ≥ 18 years of age. * Able and willing to provide written informed consent. * Able and willing to comply with the study protocol. Exclusion Criteria: * Previous lung resection surgery. * Previous chest radiation. * Patient has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples. * In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia. * Pregnancy.

Locations (1)

Firestone Institute for Respiratory Health, Research - St. Joseph's Healthcare

Hamilton, Ontario, Canada

Outcomes

Primary Outcomes

Abnormal ventilation heterogeneity assessed by Technegas V SPECT

Proportion of patients with abnormal ventilation heterogeneity, assessed by Technegas V SPECT, prior to lung resection for lung cancer.

Time frame: Baseline

Abnormal ventilation heterogeneity assessed by 129Xe MRI

Proportion of patients with abnormal ventilation heterogeneity, assessed by 129Xe MRI, prior to lung resection for lung cancer.

Time frame: Baseline

Secondary Outcomes

Technegas V SPECT ventilation heterogeneity and luminal cellular inflammation

Proportion of patients with preoperative luminal cellular inflammation in the preoperative ventilation heterogeneity normal and abnormal groups, assessed by Technegas V SPECT.

Time frame: Baseline

129Xe MRI ventilation heterogeneity and luminal cellular inflammation

Proportion of patients with preoperative luminal cellular inflammation in the preoperative ventilation heterogeneity normal and abnormal groups, assessed by 129Xe MRI.

Time frame: Baseline

Incidence of post-operative pulmonary complications (PPC): Technegas V SPECT ventilation heterogeneity

Difference in incidence of PPC and related impact measures in preoperative ventilation heterogeneity normal and abnormal patients, assessed by Technegas V SPECT

Time frame: up to 4 weeks

Incidence of PPC: 129Xe MRI ventilation heterogeneity

Difference in incidence of PPC and related impact measures in preoperative ventilation heterogeneity normal and abnormal patients, assessed by 129Xe MRI.

Time frame: up to 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.