Eligible eyes are randomly assigned into two groups. Group A receive Fasudil eye drops (concentration 0.5 percent) twice daily. Group B, receive artificial tears drop with the same frequency. Retinal specialists who are expert in Retinopathy Of Prematurity field will perform fundus examination regularly. The examiners are blind. The progression of normal retinal vascularization and need to treatment will be documented and compared between the two study groups. The topical eye drops are used until the retinal vascularization are complete (45 week after LMP) or the patient needs to be treated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
184
receive Fasudil eye drops (concentration 0.5 percent) twice daily
receive artificial tears drop with the same frequency
Ophthalmic Research Center
Tehran, Iran
RECRUITINGStimulation of normal retinal vascularization and disease progression inhibition
Fundoscopy and examiner judgment which will be documented by retinal camera
Time frame: 3 months
Any adverse event
Neonatologist and ophthalmologist examination
Time frame: 3 months
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