Effects of Red Blood Cells Transfusion on Renal Blood Flow

N/ACompletedNCT04194047

Università degli Studi di Ferrara33 enrolled

Overview

The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acute Kidney Injury Transfusion-Associated Circulatory Overload Anemia Fluid Overload

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 and \< 90 * Hemoglobin ≥7 and ≤ 10 g/dl Exclusion Criteria: * Ultrasound RRI evaluation non available * Patients with arrhythmia * Pregnancy * Refusal to give consent * History of renal transplantation * Central venous access in superior vena cava not available Critical active bleeding

Outcomes

Primary Outcomes

Change in renal resistivity index (RRI) after intervention

To compare change in RRI after intervention between groups. Values over\>0.70 are considered pathological. Higher values means worse outcome.

Time frame: after 60 minute from intervention

Change Renal Venous Stasis Index (RSVI) after intervention

To compare change in RSVI after intervention between groups. Under physiological conditions, the index is zero. Higher values means worse outcome.

Time frame: after 60 minute from intervention

Secondary Outcomes

Occurence of AKI

Occurence of AKI as defined by Kidney Disease: Improving Global Outcomes (KDIGO)

Time frame: Once a day for 7 days

Variation in renal resistivity index (RRI)

To compare change in RRI after intervention between groupsValues over\>0.70 are considered pathological. Higher values means worse outcome.

Time frame: after 24 hours from intervention

Variation in Renal Venous Stasis Index (RSVI)