Cytoflavin in the Rehabilitation of Post-intensive Care Syndrome in Stroke Survivors

Inclusion Criteria: * Men and women aged 18 years and above; * Patients who underwent ischemic stroke; * The period from the development of ischemic stroke is not less than 12 and not more than 28 days; * Staying in intensive care unit for no less than 72 hours; * Diagnosed post-intensive care syndrome (PICS); * Functional status assessed using the modified Rankin scale amounts to 4-5; * Gravity gradient of 20° to 40° upon inclusion in observational non-interventional program Exclusion Criteria: * Vegetative state; * Mechanical ventilation lasting more than 72 hours after the development of ischemic stroke; * Surgical treatment for cerebral stroke (decompressive craniectomy; thromboextraction etc.); * Premorbid (before the development of ischemic stroke) level of functional activity assessed using the modified Rankin scale amounts to 4 or 5; * Signs of increasing neurological deficit or enlargement of hypoperfusion zones on CT scans within 24 hours before inclusion in observational non-interventional program; * Level of consciousness ≤ 5 according to Glasgow Coma Scale and/or ≥ 1 according to Richmond Agitation-Sedation Scale (RASS); * Behavioral Pain Scale (BPS) or Visual Analogue Scale assessment score of more than \> 0 at the moment of inclusion; * Systolic blood pressure \< 90 and \> 180 mm Hg; * Diastolic blood pressure ≥ 110 mm Hg; * Mean ABP \< 60 mm Hg; * Clinical and/or electrocardiographic signs of acute coronary syndrome (including de novo ST elevation or depression, negative T-waves amplitude formation and buildup, formation of pathological Q-wave, increase in the level of markers of myocardial injury - troponin T or I, creatine phosphokinase-MB, LDH-1), or diagnosed acute myocardial infarction occurring within a month before inclusion in observational program; * Acute heart arrhythmias; * Heart rate (HR) \< 60 or \> 100 per minute; * Spontaneous respiration rate (RR) \< 10 or \> 30 per minute; * Arterial oxygen saturation (SpO2) \< 90 %; * Venous serum glucose level ≤ 4 mmol/L; * Axillary body temperature ≥ 38.5 °C; * Hematocrit ≤ 30 %; * Level of hemoglobin ≤ 80 g/l; * Serum total protein ≤ 55 g/l; * Positive passive leg raising test (PRL-test); * Acute heart failure; * Acute respiratory failure; * Acute kidney injury; * Acute liver cell failure; * Congestive heart failure; * Chronic respiratory failure, stage greater than I; * Chronic kidney disease with estimated glomerular filtration rate using Cockcroft-Gault formula \< 60 ml/min/1.73 m2; * Clinically significant deviations in the results of complete blood count, blood chemistry, common urine analysis, except those that are acceptable according to other non inclusion criteria; * Purulent-inflammatory diseases at any location; * Refuse of the patient to undergo verticalization or exercise sessions; * Use of medicinal products belonging to the pharmaceutical therapeutic category of metabolic drugs at the time of inclusion in observational non-interventional program, as well as plans for their use during study; * Plans for use of physical rehabilitation methods other than verticalization and cycling exercise sessions during the course of the program.