Pancreatic Cancer and Carbon Ion Radiotherapy

Inclusion Criteria: * Histologically confirmed, inoperable primary or local recurrent pancreatic cancer * Written informed consent (must be available before enrollment in the trial) * Karnofsky performance score \> 60 or ECOG-status 0/1 (at least: patient should be able to take care of himself, although daily-life activity or work is not possible) * Age ≥ 18 years Exclusion Criteria: * No clear difference between tumor edge and upper gastrointestinal tract in baseline imaging * Extensive lymphatic metastases * Disability of subject to understand character and individual consequences of the clinical trial * Distant metastases * Previous radiotherapy of the upper abdomen * Active medical implants (e.g. pacemaker, defibrillator), contradicting radiotherapy at HIT * Participation in another clinical study or observation period of competing trials, respectively