The aim of this study is to determine whether dairy or plant based fats combined with fish oils can alter skeletal muscle mitochondrial, physical, and cognitive function.
Physical and cognitive function decline as we get older and this may be due to changes within the mitochondria, organelles that regulate energy production in our cells. The ability of the mitochondria to produce energy can be affected by diet, and the composition of lipids in the cell is an important factor in determining how effective our mitochondria are. Dairy and plant based lipids differ in composition and therefore may differ in their ability to affect mitochondrial function when combined with fish oils (FO). The primary objective of this study is to determine whether supplementation with dairy or plant based fats combined with fish oils can alter skeletal muscle mitochondrial function. Additional exploratory objectives are 1) skeletal muscle and physical function and 2) cognitive function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
25
12-weeks, 3x per day
12-weeks, 3x per day
Wageningen University and Research
Wageningen, Gelderland, Netherlands
Maastricht University
Maastricht, Limburg, Netherlands
Mitochondrial respiration
Ex vivo mitochondrial respiration expressed by O2flux in pmol/mg wet weight/second
Time frame: 12 weeks
Physical function
Short physical Performance Battery (SPPB)
Time frame: 12 weeks
Cognitive Function
Cambridge Neuropsychological Test Automated Battery (CANTAB)
Time frame: 12 Weeks
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