Comparison of Volume Assist Control, Dual Mode and Airway Pressure Release Ventilation.

N/ACompletedNCT04196738

University Hospital, Angers20 enrolled

Overview

The aim of the COMIX-R study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

ARDS

Interventions

ventilation strategyOTHER

Patients are ventilated in randomised order with three different ventilation strategies: volume assist control (constant flow), Dual Mode or Airway Pressure Released Ventilation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * Invasive mechanical ventilation on tracheal probe * Acute respiratory distress syndrome, as defined by Berlin conference consensus, during hospitalization in intensive care, * Recovery phase of acute respiratory distress syndrome: spontaneous ventilation representing from 20 to 30% of ventilation in APRV mode. * No severe acidosis (pH\> 7.30) * Patient affiliated to or beneficiary of a health care plan * Express consent of the patient or his/her SDM Exclusion Criteria: * Pneumothorax * Contraindication to the insertion of a nasogastric tube with an esophageal balloon * Contraindication to the use of Electrical impedance tomography (pacemaker) * Pregnancy, lactating or parturient woman

Locations (1)

University hospital

Angers, France

Outcomes

Primary Outcomes

change of PaO2 (mmHg)

Arterial partial pressure of dioxygen Of note: As it is a physiological study, all the primary and secondary outcomes will be analyzed with the same importance.