Biological Effect of Vitamin D in Patients With Urothelial Carcinoma

Inclusion Criteria: * Men and women older than 18 years * Patients willing and able to read and understand the patient's information sheet and give their consent * Histologically confirmed diagnosis of urothelial non-muscle-invasive bladder cancer (T1 high grade and/or carcinoma in situ), and patients with muscle-invasive or high urinary tract carcinoma without evidence of distant metastasis (T2-4N0M0) * Candidate patients to undergo treatment by radical cystectomy or nephroureterectomy as part of conventional tumor treatment. * Not having received any antitumor treatment during the 4 weeks prior the administration of Vitamin D * Life expectancy longer than 6 months * Karnofsky Index \> 70% * Confirmed adequate bone marrow, kidney and liver functions by: 1. Leukocyte count \> 4.000 2. Platelet count \> 100.000 3. Haemoglobin levels \> 10 gr/dl 4. Serum bilirubin levels \< 1,5X the upper limit of normality 5. AST and ALT levels \< 2,5X the upper limit of normality 6. Alkaline Phosphatase levels \< 5X the upper limit of normality 7. Serum creatinine levels ≤ 2 mg/dl, and/or GFR ≥ ml/min/1.73m2 estimated by MDRD-4 IDMS or CKD-EPI evaluation * Plasma calcium levels between 8.8 and 10.6 mg/dl, and 24 hours urine calcium levels between 100 and 300 mg/24h * Women of childbearing potential should use a highly effective contraceptive method according the Clinical Trial Facilitation Group (such as combined hormonal contraceptives or IUD), and should continue its use for 90 days after the last dose of Vitamin D * Males in fertile age, with potentially fertile partner, should use a contraceptive method such as sexual abstinence or barrier method (condom), throughout the clinical trial and up to 90 days after the end of treatment, or be vasectomized Exclusion Criteria: * Ade older than 80 years * Patients with non-urothelial histology. Those with mixed histology may be included if the urothelial component is the predominant (\> 50%) * Administration of neoadjuvant chemotherapy * Administration of radiotherapy during the period between TUR and surgery * Medical history of another neoplasm diagnosed in the previous 3 years (except carcinoma in situ or non-melanoma cutaneous carcinoma). It may be included those patients with history of other neoplasms, provided that after receiving radical treatment do not relapsed * History of hypersensitivity to Vitamin D * History of renal lithiasis larger than 5 mm or symptomatic in the year prior its inclusion in the study, and/or nephrocalcinosis * History of hypercalcemia and/or hypercalciuria * Situation of hypervitaminosis (25-OH Vitamin D \> 50 ng/ml) * Previous treatment with Vitamin D in the last 6 months * Chronic treatment with corticosteroids * Other serious diseases or medical processes such as: infection that requires systemic anti-infective treatment or not controlled serious medical processes, including severe heart disease (episodes of ischemic heart disease in the last 6 months, cardiac arrhythmia or heart failure) * Medical history of sarcoidosis or parathyroid disease * History of malabsorption syndrome (for example pancreatic insufficiency, celiac disease or Crohn's disease), history of small bowled resection or any medical condition that may interfere with Vitamin D absorption * Patients who are expected to administer nutritional supplements containing Vitamin D, or who are being treated with drugs (or combination of drugs) that contain Vitamin D * Pregnancy